Abdullah Sami Madhun

Telefon: 947 85 883

Curriculum Vitae

Personal information
Name: Abdullah Sami Madhun
Address: Havforskningsinstituttet  / Institute of Marine Research
P.Box 1870 Nordnes
NO-5817 Bergen,
Norway
Telephone(s) +47 55 23 63 60
Mobile: +47 947 85 883
E-mail: abdullah.madhun@imr.no

Work experience

-Researcher (2012-): Institute of Marine Research, Bergen, Norway
-Head of Research Group (2010-2012): Health group, Institute of Marine Research, Bergen, Norway
-Senior Researcher (2003-2009): Influenza Centre, Medicine Faculty, University of Bergen, Norway.
-Senior Scientific officer (1999-2002): Vaccine section, Pharmaceutical Department, Norwegian Medicines Agency, Oslo, Norway.
-Teaching/research assistant (1993-1994): Biology and Biochemistry Department, BirZeit University, Palestine

Education and training
-Dr. Scient. Virology/Immunology (1997-1998): Department of Molecular Biology, University of Bergen, Norway.
-M. Phil. Health Sciences (1994-1996): Department of Molecular Biology/Centre for International Health, University of Bergen, Norway
-Teaching Certificate (1991-1993): Department of Education, BirZeit University, West Bank, Palestine.
-B.Sc. Biology (1985-1992): Biology and Biochemistry Department, BirZeit University, West Bank, Palestine.

Scientific Grants
-Flupan (EU; FP5) “Preparing for an Influenza Pandemic” (2003-2007). Partners from the France, Italy, UK and Norway.
-Panfluvac (EU; FP6) "Efficacious vaccine formulation system for prophylactic control of influenza pandemics” (2007-11). Partners from the Netherlands, Germany, Italy, UK, Switzerland and Norway.
-Naspanvac” (EU; FP7) “Nasal pandemic influenza vaccine” (2008-11). Partners from UK, Ireland, France and Norway.
-Globvac (NFR, project leader) “The immunogenicity and protective efficacy of plant-derived influenza H5N1 vaccine in preclinical models”, (2008-11). Partners in from Germany, UK, USA and Norway.

Scientific Publications
• Jul-Larsen A., Madhun A., Brokstad K., Montomoli E., Yusibov V. and Cox R. The human potential of a recombinant pandemic influenza vaccine produced in tobacco plants. Human Vaccines & Immunotherapeutics.2012. (in press)
• Pedersen G.K., Madhun A.S., Breakwell L, Hoschler K., Sjursen H., Pathirana R., Goudsmit J. and Cox R.J. Th1 Cells Elicited by H5N1 Vaccination Predict Seroprotection. J Infect Dis. 2012. (in press)
• Svindland, S. C., Jul-Larsen, A., Pathirana, R., Andersen, S., Madhun, A., Montomoli, E., Jabbal-Gill, I. and Cox, R. J., The mucosal and systemic immune responses elicited by a chitosan-adjuvanted intranasal influenza H5N1 vaccine. Influenza Other Respi Viruses 2012. (in press)
• Pedersen, G., Major, D., Roseby, S., Wood, J., Madhun, A. S. and Cox, R. J., Matrix-M adjuvanted virosomal H5N1 vaccine confers protection against lethal viral challenge in a murine model. Influenza Other Respi Viruses 2011. 5: 426-437.
• Madhun, A. S., Haaheim, L. R., Nostbakken, J. K., Ebensen, T., Chichester, J., Yusibov, V., Guzman, C. A. and Cox, R. J., Intranasal c-di-GMP-adjuvanted plant-derived H5 influenza vaccine induces multifunctional Th1 CD4+ cells and strong mucosal and systemic antibody responses in mice. Vaccine 2011. 29: 4973-4982.
• Cox, R. J., Pedersen, G., Madhun, A. S., Svindland, S., Saevik, M., Breakwell, L., Hoschler, K., Willemsen, M., Campitelli, L., Nostbakken, J. K., Weverling, G. J., Klap, J., McCullough, K. C., Zambon, M., Kompier, R. and Sjursen, H., Evaluation of a virosomal H5N1 vaccine formulated with Matrix M adjuvant in a phase I clinical trial. Vaccine 2011. 29: 8049-8059.
• Taranger, G.L. Svåsand, T., Madhun A.S. og Boxaspen K.K. (Ed.,). Risk assessment – environmental impacts of Norwegian aquaculture. Extracts from “Fisken og havet, særnummer 3-2010” printed August 2011. 52s.
• Madhun, A. S., Akselsen, P. E., Sjursen, H., Pedersen, G., Svindland, S., Nostbakken, J. K., Nilsen, M., Mohn, K., Jul-Larsen, A., Smith, I., Major, D., Wood, J. and Cox, R. J., An adjuvanted pandemic influenza H1N1 vaccine provides early and long term protection in health care workers. Vaccine 2010. 29: 266-273.
• Taranger, G.L. Svåsand, T., Madhun A.S. og Boxaspen K.K. (Ed.,). Risikovurdering miljøvirkninger av norsk fiskeoppdrett 2010. Fisken og havet særnr 3-2010. 93s.
• Madhun, A. S., Haaheim, L. R., Nilsen, M. V. and Cox, R. J., Intramuscular Matrix-M-adjuvanted virosomal H5N1 vaccine induces high frequencies of multifunctional Th1 CD4+ cells and strong antibody responses in mice. Vaccine 2009. 27: 7367-7376.
• Hauge, S., Madhun, A. S., Major, D., Brokstad, K. A., Vogel, F. R., Zambon, M., Wood, J., Haaheim, L. R. and Cox, R. J., The immunogenicity of a cell-derived H7N1 split influenza virion vaccine in mice. Scand J Immunol 2009. 69: 576-578.
• Cox, R. J., Major, D., Hauge, S., Madhun, A. S., Brokstad, K. A., Kuhne, M., Smith, J., Vogel, F. R., Zambon, M., Haaheim, L. R. and Wood, J., A cell-based H7N1 split influenza virion vaccine confers protection in mouse and ferret challenge models. Influenza Other Respi Viruses 2009. 3: 107-117.
• Cox, R. J., Madhun, A. S., Hauge, S., Sjursen, H., Major, D., Kuhne, M., Hoschler, K., Saville, M., Vogel, F. R., Barclay, W., Donatelli, I., Zambon, M., Wood, J. and Haaheim, L. R., A phase I clinical trial of a PER.C6 cell grown influenza H7 virus vaccine. Vaccine 2009. 27: 1889-1897.
• Hauge, S., Madhun, A. S., Cox, R. J., Brokstad, K. A. and Haaheim, L. R., A comparison of the humoral and cellular immune responses at different immunological sites after split influenza virus vaccination of mice. Scand J Immunol 2007. 65: 14-21.
• Hauge, S., Madhun, A., Cox, R. J. and Haaheim, L. R., Quality and kinetics of the antibody response in mice after three different low-dose influenza virus vaccination strategies. Clin Vaccine Immunol 2007. 14: 978-983.
• Haaheim, L. R., Madhun, A. S. and Cox, R., Pandemic influenza vaccines - the challenges. Viruses 2009. 1: 1089-1109.
• Cox, R. J., Hovden, A. O., Brokstad, K. A., Szyszko, E., Madhun, A. S. and Haaheim, L. R., The humoral immune response and protective efficacy of vaccination with inactivated split and whole influenza virus vaccines in BALB/c mice. Vaccine 2006. 24: 6585-6587.
• Cox, R. J., Haaheim, L. R., Ericsson, J. C., Madhun, A. S. and Brokstad, K. A., The humoral and cellular responses induced locally and systemically after parenteral influenza vaccination in man. Vaccine 2006. 24: 6577-6580.
• Hovden, A. O., Cox, R. J., Madhun, A. and Haaheim, L. R., Two doses of parenterally administered split influenza virus vaccine elicited high serum IgG concentrations which effectively limited viral shedding upon challenge in mice. Scand J Immunol 2005. 62: 342-352.
• Madhun A, Cox R, Haaheim LR, Jonsson R, Brokstad KA. The kinetics of the systemic and local immune response to parentral influenza vaccination. (Book Chapter) In: Proceedings of the International Conference on options for the Control of Influenza V. Kawaoka Y, Ed. Elsevier B.V., Amsterdam, 2004, 515-8.
• El-Madhun, A. S., Cox, R. J. and Haaheim, L. R., The effect of age and natural priming on the IgG and IgA subclass responses after parenteral influenza vaccination. J Infect Dis 1999. 180: 1356-1360.
• el-Madhun, A. S., Cox, R. J., Soreide, A., Olofsson, J. and Haaheim, L. R., Systemic and mucosal immune responses in young children and adults after parenteral influenza vaccination. J Infect Dis 1998. 178: 933-939.
• el-Madhun, A. S., Cox, R. J., Seime, A., Sovik, O. and Haaheim, L. R., Systemic and local immune responses after parenteral influenza vaccination in juvenile diabetic patients and healthy controls: results from a pilot study. Vaccine 1998. 16: 156-160.
• El-Madhun AS. Characteristics of the humoral immune response after parenteral influenza vaccination. Dr. Scient. thesis, University of Bergen 1998. ISBN 82-7653-014-1.
• El-Madhun AS, Søreide A, Olofsson J, Cox RJ, Haaheim LR. Is influenza priming necessary to mount a mucosal immune response to parenteral influenza vaccination in small children? (Book Chapter) In: Options for the Control of Influenza III. Brown LE, Hampson AW, Webster RG, Eds. Elsevier Science B.V., Amsterdam, 1996, 113-8.
• Seime A, El-Madhun AS, Haaheim LR. Influensa vaksinering av diabetikere. Diabetikeren 1995; 6: 28-30.

Scientific meetings
-More than 35 oral or poster presentations in international and national scientific meetings.

Journal reviewer
A peer reviewer for the European Journal of Immunology, Vaccine, Scandinavian Journal of Immunology and Journal of Infectious Diseases.

Teaching and supervision experience:
-Supervising and co-supervising Master and PhD students at the University of Bergen.
-Teaching in the university courses in the fields of immunology, virology, immunological methods and vaccines.

Organisational skills and competences
-Student representative (1991-1992) at the Academic Council in Faculty of Science at BirZeit University.
-Student representative (1996-1998) at the Centre for International Health at the Faculty of Medicine, University of Bergen.
-Employee deputy representative (2003-2005) at UNIFOB, the Department for basic medicine research