Curriculum Vitae

Personal details

Name: H. Craig Morton
Date of birth: January 25th, 1968
Nationality: Scottish

Educational details

Undergraduate Education: University of Strathclyde, Glasgow, Scotland.
Dates: 1985 - 1989
Qualifications: BSc (Hons) Biochemistry and Immunology
Upper 2nd Class Honours (2.1)

Doctoral Education: University of Sheffield, Sheffield, UK.
Dates: Oct 1989 - Feb 1993
Qualifications: Ph.D.
Title of thesis: Studies on recombinant human IgA1 and IgA2.

Employment details:

May 2006 - present: Research scientist, Institute of Marine Research, Bergen, Norway

Mar 1997 - Feb 2006: Scientist position, LIIPAT, Institute of Pathology, Rikshospitalet, Oslo, Norway

Mar 1993 - Feb 1997: Post-doctoral position at the Department of Immunology, University Hospital Utrecht, Utrecht, The Netherlands.

Peer reviewed publications

Patel S, Sørhus E, Fiksdal IU, Espedal PG, Bergh O, Rødseth OM, Morton HC, Nerland AH. 2009. Ontogeny of lymphoid organs and development of IgM-bearing cells in Atlantic halibut (Hippoglossus hippoglossus L.). Fish Shellfish Immunol. 26:385.

Sandvik A, Wang YY, Morton HC, Aasen AO, Wang JE, Johansen FE. 2007. Oral and systemic administration of beta-glucan protects against lipopolysaccharide-induced shock and organ injury in rats. Clin Exp Immunol. 148:168.

Meier S, Andersen TE, Norberg B, Thorsen A, Taranger GL, Kjesbu OS, Dale R, Morton HC, Klungsoyr J, Svardal A. 2007. Effects of alkylphenols on the reproductive system of Atlantic cod (Gadus morhua). Aquat Toxicol. 81:207.

Morton HC, Pleass, RJ, Storset AK, Brandtzaeg P, Woof JM. 2005. Cloning and characterization of equine CD89 and identification of the CD89 gene in chimpanzees and rhesus macaques. Immunology 115:74.

Morton HC, Pleass RJ, Woof JM, Brandtzaeg P. 2004. Characterization of the ligand binding site of the bovine IgA Fc receptor (bFcαR). J Biol Chem. 279:54018.

Carlsen HS, Baekkevold ES, Morton HC, Haraldsen G, Brandtzaeg P. 2004. Monocyte-like and mature macrophages produce CXCL13 (B cell-attracting chemokine 1) in inflammatory lesions with lymphoid neogenesis. Blood 104:3021.

Morton HC, Pleass RJ, Storset AK, Dissen E, Williams JL, Brandtzaeg P, Woof JM. 2004. Cloning and characterization of an IgA Fc receptor from cattle (bFcαR). Immunology 111:204.

Hamre R, Farstad IN, Brandtzaeg P, Morton HC. 2003. Expression and modulation of CD89 and the FcR γ chain in blood and tissues. Scand. J. Immunol. 57:506.

Pan Q, Petit-Frére C, Dai S, Huang P, Morton HC, Brandtzaeg P, Hammarström L. 2001. Regulation of switching and production of IgA in human B cells in donors with duplicated α1 genes. Eur. J. Immunol. 31:3622.

Morton HC, Howard CJ, Storset AK, Brandtzaeg, P. 2001. Identification of residues within the extracellular domain 1 of bovine Fcγ2R essential for binding bovine IgG2. J. Biol. Chem. 276: 47794.

Morton HC, Storset AK, Brandtzaeg, P. 2001. Cloning and sequencing of a cDNA encoding the bovine FcR γ chain. Vet. Immunol. Immunopathol. 82:101.

Vidarsson G, van Der Pol WL, van Den Elsen JM, Vile H, Jansen M, Duijs J, Morton HC, Boel E, Daha MR, Corthesy B, van De Winkel JG. 2001. Activity of human IgG and IgA subclasses in immune defense against Neisseria meningitidis serogroup B. J. Immunol. 166:6250.

Yamanaka T, Straumfors A, Morton HC, Fausa O, Brandtzaeg P, Farstad IN. 2001. M cell pockets of human Peyer's patches are specialized extensions of germinal centers. Eur. J. Immunol. 31:107.

Farstad IN, Carlsen H, Morton HC, Brandtzaeg P. 2000. Immunoglobulin A cell distribution in the human small intestine: phenotypic and functional characteristics. Immunology 101:354.

Van Vuuren AJ, van Egmond M, Coenen MJ, Morton HC, van de Winkel JGJ. 1999. Characterization of the human myeloid IgA Fc receptor I (CD89) gene in a cosmid clone. Immunogenetics 49:586.

Van Egmond M, van Vuuren AJH, Morton HC, van Spriel, AB, Shen L, Hofhuis FMA, Saito T, Mayadas TN, Verbeek JS, van de Winkel JGJ. 1999. Human immunoglobulin A receptor (FcαRI, CD89) function in transgenic mice requires both FcR γ Chain and CR3 (CD11b/CD18). Blood 93: 4387.

Morton HC, van Zandbergen G, van Kooten K, Howard CJ, van de Winkel, JGJ, Brandtzaeg P. 1999. Immunoglobulin-binding sites of human FcαRI (CD89) and bovine Fcγ2R are located in their membrane-distal extracellular domains. J. Exp. Med. 189: 1715.

Reterink TJF, van Zandbergen G, Van Egmond M, Klar-Mohamad N, Morton HC, van de Winkel JGJ, Daha MR. 1997. Size-dependent effect of IgA on the IgA Fc receptor (CD89). Eur. J. Immunol. 27:2219.

Morton HC, Schiel AE, Janssen SWJ, van de Winkel, JGJ. 1996. Alternatively spliced forms of the human myeloid Fcα receptor (CD89) in neutrophils. Immunogenetics 43:246.

Morton HC, van den Herik-Oudijk IE, Vossebeld P, Snijders A, Verhoeven AJ, Capel PJA, van de Winkel, JGJ. 1995. Functional association between the human myeloid immunoglobulin A Fc receptor (CD89) and FcR γ chain. J. Biol. Chem. 270:29781.

De Wit TPM, Morton HC, Capel PJA, van de Winkel JGJ. 1995. Structure of the gene for the human myeloid IgA Fc receptor (CD89). J. Immunol. 155:1203.

Morton HC, Atkin JD, Owens RJ, Woof, JM. 1993. Purification and characterization of chimeric human IgA1 and IgA2 expressed in COS and chinese hamster ovary cells. J. Immunol. 151:4743.

Reviews

Meier S, Morton HC, Misund OA. 2008. Does the discharge of alkylphenols in produced water cause oestrogenic endocrine disruption amongst fish in the North Sea? Exploration & Production – Oil and Gas Review 6:64.

Morton HC. 2005. IgA Fc receptors in horses and cattle. Vet. Immunol. Immunopathol. 108:139.

Morton HC, Brandtzaeg P. 2001. CD89: The human myeloid IgA Fc receptor. Archivum Immunologiae et Therapiae Experimentalis 49:217.

Brandtzaeg P, Farstad IN, Johansen F-E, Morton HC, Norderhaug IN, Yamanaka T. 1999. The B-cell system of human mucosae and exocrine glands. Immunological Reviews 171:45.

Morton HC, van Egmond M, van de Winkel, JGJ. 1996. Structure and function of human IgA Fc receptors (FcαR). Crit. Rev. Immunol. 16:423.

Book chapters

Morton HC. 2007. IgA receptors. In “Mucosal Immune Defense: Immunoglobulin A”. Kluwer Academic Publishers.

Brantzaeg P, Morton HC, Lamm ME. 2004. Characteristics of mucosal B cells with emphasis on the human secretory immune system. In “Molecular Biology of B cells”. Elsevier Academic Press.

Morton HC, van Egmond M, van de Winkel JGJ. 1998. Human IgA Fc receptors. In “The Immunoglobulin Receptors and their Physiological and Pathological Roles in Immunity”. Kluwer Academic Publishers.

Commentaries

Brandtzaeg P, Baekkevold ES, Morton HC. 2001. From B to A the mucosal way. Nat Immunol. 2: 1093.

Newspaper articles

Morton HC., Rice S. 2009. Lærdommer fra Exxon Valdez. Bergens Tidende (01.12.09)