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Rolf Brudvik Edvardsen

Telefon: 909 42 948
Besøksadresse: Nordnesgaten 50 5005 Bergen, NORWAY

Arbeider med

Scientific background
My master of science (1996-1999) was carried out at the Department of Molecular Biology at the University of Bergen under the guidance of Prof. Anders Fjose. Here I studied the DNA binding properties of PAX proteins in zebrafish.
The doctoral thesis (2000-2005) was conducted at Sars Int Centre for Marine Molecular Biology under the supervision of Prof. Daniel Chourrout. Here I studied various aspects of genes and genomes of the tunicate Oikopleura dioica. From 2005 to 2010 I was Postdoctoral Fellow at IMR in the group Marin genomics under the leadership of Prof.Frank Nilsen. Here I was developing methodologies and resources in cod genomics. Since 2010 I have been a senior researcher in the research group Reproduction and Growth at IMR. From working mostly on cod the focus has shifted more over to salmon, but also halibut, haddock, calanus and salmon louse. The methodology is wide from bioinformatics studies (GWAS, epigentics, transcriptomics) to microinjections (CRISPR-cas9). The scientific questions are also differing much between the projects and the projects involve a high number of collaborators both within and outside Norway.

Curriculum Vitae

Rolf Brudvik Edvardsen (Dr.scient)
Birth date: 6.4.1973
Civil status: Married, two children
Senior scientist

FORMAL EDUCATION:

2000-2005 Doctorate degree at Institute of Molecular Biology and Sars Int Centre, University of Bergen, Norway
1992-1999 Master in Molecular biology, University of Bergen

PUBLICATIONS IN INTERNATIONAL JOURNALS

Erik Kjærner-Semb,, Fernando Ayllon, Tomasz Furmanek, Vidar Wennevik, Geir Dahle, Niemelä Eero, Mikhail Ozerov, Kevin A Glover,, Carl J Rubin, Anna Wargelius, Rolf B Edvardsen (2016) Atlantic Salmon Populations Reveal Adaptive Divergence of Immune Related Genes - A duplicated genome under selection. BMC Genomics In press

Ragnhild Valen, Mariann Eilertsen, Rolf Brudvik Edvardsen, Tomasz Furmanek, Ivar Rønnestad, Terje van der Meeren, Ørjan Karlsen Tom Nilsen and Jon Vidar Helvik (2016) From simplex- to duplex: Potentials of using an indirect developing retina as a natural model for two-step photoreceptor neurogenesis and development. Developmental Biology in press

Anna Wargelius, Sven Leininger, Kai Ove Skaftnesmo, Lene Kleppe, Eva Andersson, Geir Lasse Taranger, Rüdiger W Schulz, Rolf B Edvardsen (2016) CRISPR-Cas9-mediated dead end knock-out in Atlantic salmon leads to germ cell deficient fish and demonstrates germ cell independent sex differentiation. Scientific Reports, doi:10.1038/srep21284

Elin Sørhus, John P. Incardona, Tomasz Furmanek, Sissel Jentoft, Sonnich Meier and Rolf B. Edvardsen (2016) Developmental transcriptomics in Atlantic haddock: Illuminating pattern formation and organogenesis in non-model vertebrates. Developmental Biology, doi: 10.1016/j.ydbio.2016.02.012.

Teshome Tilahun Bizuayehu, Tomasz Furmanek, Ørjan Karlsen,, Terje van der Meeren, Rolf B Edvardsen, Ivar Rønnestad, Kristin Hamre, Steinar D Johansen, Igor Babiak (2016) First feed affects expression of microRNAs and their targets in Atlantic cod. British Journal of Nutrition doi:10.1017/S0007114516000155

Ayllon F, Kjærner-Semb E, Furmanek T, Wennevik V, Solberg MF, Dahle G, Taranger GL, Glover KA, Almén MS, Rubin CJ, Edvardsen RB, Wargelius A (2015) The vgll3 locus controls age at maturity in wild and domesticated Atlantic salmon (Salmo salar L.) males. Plos genetics, Nov12 2015, DOI:10.1371/journal.pgen.1005628

Samuel J Penglase, Rolf B Edvardsen, Tomasz Furmanek, Ivar Rønnestad, Ørjan Karlsen, Terje van der Meeren and Kristin Hamre (2015) Diet affects the redox system in developing Atlantic cod (Gadus morhua) larvae. Redox Biology 5, 08–18. DOI: 10.1016/j.redox.2015.06.00

Anna Wargelius, Tomasz Furmanek, Jérôme Montfort, Aurélie Le Cam, Lene Kleppe, Rolf B Edvardsen, Geir Lasse Taranger and Julien Bobe (2015) A comparison between egg transcriptomes of cod and salmon-reveals species specific traits in eggs for each species . Molecular Reproduction and Development doi: 10.1002/mrd.22487

Kleppe L., Wargelius A., Nilsen H., Taranger GL. and Edvardsen, RB. (2015). Gonad specific genes in Atlantic salmon (Salmon salar L.) : characterization of tdrd7, tdrd1, dazl and ziwi genes. Gene doi: 10.1016/j.gene.2015.02.008.

Elin Sørhus, Rolf B. Edvardsen, Sissel Jentoft, Ørjan Karlsen, Trond Nordthug, Terje van der Meeren, Anders Thorsen, Christopher Harman, Sonnich Meier. (2015). Evidence for high sensitivity to oil exposure and enhanced embryotoxicity during early life stages of the marine teleost- Atlantic haddock (Melanogrammus aeglefinus ). PLoS ONE doi: 10.1371/journal.pone.0124376

Rolf B Edvardsen, Sven Leininger, Lene Kleppe, Kai Ove Skaftnesmo, Anna Wargelius. (2014). Targeted mutagenesis in Atlantic salmon (Salmo salar L.) using the CRISPR/Cas9 system induces complete knockout individuals in the F0 generation.  PLoS ONE 9(9): e108622. doi:10.1371/journal.pone.0108622

Ragnhild Valen*, Rolf Brudvik Edvardsen*, Anne Mette Søviknes, Øyvind Drivenes and Jon Vidar Helvik. (2014). Molecular evidence that only two opsin families, the blue light- (SWS2) and green light-sensitive (RH2), drive color vision in Atlantic cod (Gadus morhua). PLoS ONE 9(12): e115436. doi:10.1371/journal.pone.0115436. *equal contributions

Edvardsen RB, Dalvin S, Furmanek T, Malde K, Mæhle S, Kvamme BO and Skern-Mauritzen R. (2014). Gene expression in five salmon louse (Lepeophtheirus salmonis, Krøyer 1837) tissues. Marine Genomics http://dx.doi.org/10.1016/j.margen.2014.06.008

Francois Besnier, Matthew P Kent, Rasmus Skern-Mauritzen,, Sigbjørn Lien, Ketil Malde, Rolf B Edvardsen, Simon Taylor, Lina E R Ljungfeldt, Frank Nilsen and Kevin A Glover. (2014) Human-induced evolution caught in action: SNP-array reveals rapid amphi-Atlantic spread of pesticide resistance in the salmon ecotoparasite Lepeophtheirus salmonis. BMC Genomics doi:10.1186/1471-2164-15-937

Mariann Eilertsen, Øyvind Drivenes, Rolf B. Edvardsen, Clarrisa A. Bradley, Lars O.E. Ebbesson and Jon Vidar Helvik. (2014). Melanopsin and exorhodopsin in the pineal complex of Atlantic halibut (Hippoglossus hippoglossus). Journal of Comparative Neurology Jul 18. doi: 10.1002/cne.23652

Lene Kleppe, Rolf Brudvik Edvardsen, Tomasz Furmanek, Geir Lasse Taranger, Anna Wargelius. (2014). Global
transcriptome analysis identifies regulated transcripts and pathways activated during oogenesis and early embryogenesis in Atlantic cod. Molecular Reproduction and Development, doi: 10.1002/mrd.22328

Kleppe, L., Karlsen, Ø., Edvardsen, R.B., Norberg, B., Andersson, E., Taranger, GL., Wargelius, A. (2013). Cortisol treatment of prespawning female cod affects cytogenesis related factors in eggs and embryos. Gen Comp Endocrinol, doi: 10.1016/j.ygcen.2013.04.028

Bratberg, B., Olsvik, P.A., Edvardsen, R.B., Brekken, H.K., Vadla, R., Meier, S. (2013) Effects of oil pollution and persistent organic pollutants (POPs) on glycerophospholipids in liver and brain of male Atlantic cod (Gadus morhua). Chemosphere, 90, 2157-2171

Kleppe, L., Edvardsen, R.B., Kuhl, H., Malde, K., Furmanek, T., Drivenes, Ø., Reinhardt, R., Taranger, GL., Wargelius A (2012) Maternal 3’UTRs: from egg to onset of zygotic transcription in Atlantic cod. BMC Genomics, 13:443

Morais, S., Edvardsen, R.B., Tocher, D.R., Bell, J. G. (2012). Transcriptomic analyses of intestinal gene expression of juvenile Atlantic cod (Gadus morhua) fed diets with increasing proportions of Camelina oil as replacement for fish oil. Comparative Biochemistry and Physiology, Mar;161(3):283-93

Drivenes, Ø., Taranger, GL and Edvardsen, R.B (2012) Gene expression profiling of Atlantic cod (Gadus morhua) embryogenesis using microarray. Mar Biotechnology, 14(2):167-176

Star, B et al., 43 authors including Edvardsen, R.B. (2011) The genome sequence of Atlantic cod reveals a unique immune system. Nature,  Aug 10.

Hildahl, J., Sandvik, G.K., Edvardsen, R.B., Fagernes, C., Norberg, B., Haug, T.M., Weltzien,
F.A (2011) Four gonadotropin releasing hormone receptor genes in Atlantic cod are differentially expressed in the brain and pituitary during puberty. Gen Comp Endocrinol, Sep 1;173(2):333-45

Hildahl, J., Sandvik, G.K., Edvardsen, R.B., Fagernes, C., Norberg, B., Haug, T.M., Weltzien,
F.A (2011). Identification and gene expression analysis of three GnRH genes in female Atlantic cod during puberty provides insight into GnRH variant gene loss in fish. Gen Comp Endocrinol.  Jul 1;172(3):458-67

Edvardsen, R.B., Malde, K., Mittelhozer, C., Taranger ,GL., Nilsen, F (2011) EST resources and establishment and validation of a 16k cDNA microarray from Atlantic cod (Gadus morhua). Comparative Biochemistry and Physiology D-Genomics & Proteomics 6, 23-30.

Johansen, S.D., Karlsen, B.O., Furmanek, T., Andreassen, M., Jorgensen, T.E., Bizuayehu, T.T., Breines, R., Emblem, A., Kettunen, P., Luukko, K., Edvardsen, R.B., Nordeide, J.T., Coucheron, D.H., Moum, T  (2011). RNA deep sequencing of the Atlantic cod transcriptome. Comparative Biochemistry and Physiology D-Genomics & Proteomics 6, 18-22.

Kamisaka, Y., Jordal, A.E.O., Edvardsen, R.B., Kryvi, H., Otterlei, E., Ronnestad, I., (2010) A case report on the distended gut syndrome (DGS) in cultured larvae of Atlantic cod (Gadus morhua). Aquaculture 309, 38-48.

Wetten, O.F., Nederbragt, A.J., Wilson, R.C., Jakobsen, K.S., Edvardsen, R.B., Andersen, O.,
(2010) Genomic organization and gene expression of the multiple globins in Atlantic cod: conservation of globin-flanking genes in chordates infers the origin of the vertebrate globin clusters. BMC Evolutionary Biology 10, -.

Chourrout D, Delsuc F, Chourrout P, Edvardsen RB, Rentzsch F, Renfer E, Jensen
MF, Zhu B, de Jong P, Steele RE, Technau U (2006) Minimal protohox cluster inferred from bilaterian and cnidarian Hox complements. Nature, 442:684-7

Edvardsen RB, Seo HC, Jensen MF, Mialon A, Mikhaleva J, Bjordal M, Cartry J, Reinhardt R, Weissenbach J, Wincker P, Chourrout D (2005) Remodelling of the homeobox gene complement in the tunicate Oikopleura dioica. Curr Biol 15:R12-3

Edvardsen RB, Lerat E, Maeland AD, Flat M, Tewari R, Jensen MF, Lehrach H, Reinhardt R, Seo HC, Chourrout D (2004)Hypervariable and highly divergent intron-exon organizations in the chordate Oikopleura dioica. J Mol Evol 59:448-57

Seo HC, Edvardsen RB, Maeland AD, Bjordal M, Jensen MF, Hansen A, Flaat M, Weissenbach J, Lehrach H, Wincker P, Reinhardt R, et al. (2004) Hox cluster disintegration with persistent anteroposterior order of expression in Oikopleura dioica. Nature 431:67-71

Nilsen IW, Myrnes B, Edvardsen RB, Chourrout D (2003) Urochordates carry multiple genes for goose-type lysozyme and no genes for chicken- or invertebrate-type lysozymes. Cell Mol Life Sci 60:2210-8

Seo HC, Kube M*, Edvardsen RB*, Jensen MF, Beck A, Spriet E, Gorsky G, Thompson EM, Lehrach H, Reinhardt R, Chourrout D (2001) Miniature genome in the marine chordate Oikopleura dioica. Science 294:2506  *equal contributions