Kai Ove Skaftnesmo

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Senioringeniør
Telefon: 55238500
Avdeling: Reproduksjon og utviklingsbiologi

Publikasjoner

Poster

2014

Small RNAs in immature and mature testis of Atlantic Salmon (Salmo Salar L.).

Skaftnesmo, Kai Ove
2014

SMALL RNAS IN IMMATURE AND MATURE TESTIS OF ATLANTIC SALMON (SALMO SALAR L.)

Kai Ove Skaftnesmo, Rolf Edvardsen, Tomasz Furmanek, Eva Andersson, Lene Kleppe, Jan Bogerd, Rüdiger W. Schulz, Geir Lasse Taranger, Anna Wargelius
2009

Highly infiltrative brain tumors show reduced chemosensitivity associated with a stem cell-like phenotype

Tor-Christian Aase Johannessen, Jian Wang, Kai Ove Skaftnesmo, Per Øystein Sakariassen, Per Øyvind Enger, Kjell Petersen, Anne Margrete Øyan, Karl-Henning Kalland, Rolf Bjerkvig, Berit Bølge Tysnes

Vitenskapelige artikler (NVI)

2018

Vgll3 and the Hippo pathway are regulated in Sertoli cells upon entry and during puberty in Atlantic salmon testis

Erik Nordtorp Kjærner-Semb, Fernando Ayllon, Lene Kleppe, Elin Sørhus, Kai Ove Skaftnesmo, Tomasz Furmanek, Frida Thyri Segafredo, Anders Thorsen, Per Gunnar Fjelldal, Tom Johnny Hansen, Geir Lasse Taranger, Eva Andersson, Rüdiger W. Schulz, Anna Wargelius, Rolf Edvardsen
Scientific Reports 8:1912 p. 1-11
2017

Sex steroid production associated with puberty is absent in germ cellfree salmon

Lene Kleppe, Eva Andersson, Kai Ove Skaftnesmo, Rolf Edvardsen, Per Gunnar Fjelldal, Birgitta Norberg, Jan Bogerd, Rüdiger W. Schulz, Anna Wargelius
Scientific Reports 7
2017

Integrative testis transcriptome analysis reveals differentially expressed miRNAs and their mRNA targets during early puberty in Atlantic salmon

Kai Ove Skaftnesmo, Rolf Edvardsen, Tomasz Furmanek, D. Crespo, Eva Andersson, Lene Kleppe, Geir Lasse Taranger, Jan Bogerd, Rüdiger W. Schulz, Anna Wargelius
BMC Genomics 18
2016

Dnd knockout ablates germ cells and demonstrates germ cell independent sex differentiation in Atlantic salmon

Anna Wargelius, Sven Dirk Leininger, Kai Ove Skaftnesmo, Lene Kleppe, Eva Andersson, Geir Lasse Taranger, Rüdiger W. Schulz, Rolf Edvardsen
Scientific Reports 6
2015

Melanoma brain metastasis is independent of lactate dehydrogenase A expression

Terje Sundstrøm, Heidi Espedal, Patrick N. Harter, Kristine Eldevik Fasmer, Kai Ove Skaftnesmo, Sindre August Horn, Erlend Hodneland, Michel Mittelbronn, Benjamin Weide, Rudi Beschorner, Benjamin Bender, Cecilie Brekke Rygh, Morten Lund-Johansen, Rolf Bjerkvig, Frits Thorsen
Neuro-Oncology 17 p. 1374-1385
2015

Intercellular transfer of transferrin receptor by a contact-, Rab8-dependent mechanism involving tunneling nanotubes

Anne Pierrette Burtey, Marek Wagner, Erlend Hodneland, Kai Ove Skaftnesmo, Julia Schölermann, Ivan Rios Mondragon, Heidi Espedal, Anna Golebiewska, Simone Niclou, Rolf Bjerkvig, Tanja Kögel, Hans-Hermann Gerdes
The FASEB Journal 29 p. 4695-4712
2015

A novel nanoprobe for multimodal imaging is effectively incorporated into human melanoma metastatic cell lines

Synnøve Nymark Aasen, Aneta Pospíšilová, Tilo Wolf Eichler, Jiří Pánek, Martin Hrubý, Petr Štěpánek, Endy Spriet, Daniel Jirák, Kai Ove Skaftnesmo, Frits Thorsen
International Journal of Molecular Sciences 16 p. 21658-21680
2014

A co-culture model with brain tumor-specific bioluminescence demonstrates astrocytes-induced drug resistance in glioblastoma.

Ning Yang, Tao Yan, Huaiyang Zhu, Xiao Liang, Lina Wik Leiss, Per Øystein Sakariassen, Kai Ove Skaftnesmo, Bin Huang, Daniela Elena Costea, Per Øyvind Enger, Xingang Li, Jian Wang
Journal of Translational Medicine 12:278
2014

In vitro treatment of melanoma brain metastasis by simultaneously targeting the MAPK and PI3K signaling pathways

Inderjit Kaur Daphu, Sindre August Horn, Daniel Stieber, Jobin K. Varughese, Endy Spriet, Hege Avsnes Dale, Kai Ove Skaftnesmo, Rolf Bjerkvig, Frits Alan Thorsen
International Journal of Molecular Sciences 15 p. 8773-8794
2014

Targeted mutagenesis in Atlantic salmon(Salmo salar L.)Using the CRISPR/Cas9 system induces Complete knockout individuals in the F0 generation

Rolf Edvardsen, Sven Dirk Leininger, Lene Kleppe, Kai Ove Skaftnesmo, Anna Wargelius
PLoS ONE 9 p. 1-7
2013

Targeting glioblastoma with NK cells and mAb against NG2/CSPG4 prolongs animal survival

Aurélie Poli, Jian Wang, Olivia Domingues, Jesus Planaguma, Tao Yan, Cecilie Brekke, Kai Ove Skaftnesmo, Frits Alan Thorsen, Emmet McCormack, François Hentges, Paal-Henning Pedersen, Jacques Zimmer, Per Øyvind Enger, Martha Chekenya
OncoTarget 4 p. 1527-1546
2013

Multimodal imaging enables early detection and characterization of changes in tumor permeability of brain metastases

Frits Alan Thorsen, Brett Fite, Lisa M. Mahakian, Jai W. Seo, Shengping Qin, Harrison Victoria, Sarah Johnson, Elizabeth Ingham, Charles Caskey, Terje Sundstrøm, Thomas J. Meade, Patrick Harter, Kai Ove Skaftnesmo, Katherine W. Ferrara
Journal of Controlled Release 172 p. 812-822
2013

EGFR wild-type amplification and activation promote invasion and development of glioblastoma independent of angiogenesis

Krishna Mukharji Talasila, Anke Soentgerath, Philipp Euskirchen, Gro Vatne Røsland, Jian Wang, Peter Csaba Huszthy, Lars Prestegarden, Kai Ove Skaftnesmo, Per Øystein Sakariassen, Eskil Eskilsson, Daniel Stieber, Olivier Keunen, Narve Brekkå, Ingrid Moen, Janice Marie Nigro, Olav Karsten Vintermyr, Morten Lund-Johansen, Simone P Niclou, Sverre Mørk, Per Øyvind Enger, Rolf Bjerkvig, Hrvoje Miletic
Acta Neuropathologica 125 p. 683-698
2013

Automated tracking of nanoparticle-labeled melanoma cells improves the predictive power of a brain metastasis model

Terje Sundstrøm, Inderjit Kaur Daphu, Ingvild Haukaas Wendelbo, Erlend Hodneland, Arvid Lundervold, Heike Immervoll, Kai Ove Skaftnesmo, Michal Babic, Pavla Jendelova, Eva Sykova, Morten Lund-Johansen, Rolf Bjerkvig, Frits Alan Thorsen
Cancer Research 73 p. 2445-2456
2012

MicroRNA regulation of the synaptic plasticity-related gene arc

Karin Wibrand, Pai Balagopal Sreenivasa, Taweeporn Siripornmongcolchai, Margarethe Bittins, Birgitte Berentsen, May Lillian Ofte, Arwed Weigel, Kai Ove Skaftnesmo, Clive R. Bramham
PLoS ONE 7
2011

Neuronal markers are expressed in human gliomas and NSE knockdown sensitizes glioblastoma cells to radiotherapy and temozolomide

Tao Yan, Kai Ove Skaftnesmo, Lina Wik Leiss, Linda Sleire, Jian Wang, XinGang Li, Per Øyvind Enger
BMC Cancer 20
2011

NUMB does not impair growth and differentiation status of experimental gliomas

Philipp Euskirchen, Kai Ove Skaftnesmo, Peter Csaba Huszthy, Narve Brekkå, Rolf Bjerkvig, Andreas H. Jacobs, Hrvoje Miletic
Experimental Cell Research 317 p. 2864-2873
2011

Targeting the NG2/CSPG4 Proteoglycan Retards Tumour Growth and Angiogenesis in Preclinical Models of GBM and Melanoma

Jian Wang, Agnete Svendsen, Justyna Kmiecik, Heike Immervoll, Kai Ove Skaftnesmo, Jesus Planaguma, Rolf K. Reed, Rolf Bjerkvig, Hrvoje Miletic, Per Øyvind Enger, Cecilie Brekke, Martha Chekenya
PLoS ONE 6
2010

alpha B-Crystallin Is Elevated in Highly Infiltrative Apoptosis-Resistant Glioblastoma Cells

Dorota Goplen, Sébastien Bougnaud, Uros Rajcevic, Stig Ove Bøe, Kai Ove Skaftnesmo, Jurgen Voges, Per Øyvind Enger, Jian Wang, Berit Bølge Tysnes, Ole Didrik Lærum, Simone P Niclou, Rolf Bjerkvig
American Journal of Pathology 177 p. 1618-1628
2010

Glioma cell populations grouped by different cell type markers drive brain tumor growth

Lars Prestegarden, Agnete Svendsen, Jian Wang, Linda Sleire, Kai Ove Skaftnesmo, Rolf Bjerkvig, Tao Yan, Lasse Haugen Askland, Andreas Persson, Per Øystein Sakariassen, Per Øyvind Enger
Cancer Research 70 p. 4274-4279
2010

Differential regulation of mature and precursor microRNA expression by NMDA and metabotropic glutamate receptor activation during LTP in the adult dentate gyrus in vivo

Karin Wibrand, Debabrata Panja, Adrian Tiron, May Lillian Ofte, Kai Ove Skaftnesmo, Cherin S-Lee, John T.G. Pena, Thomas Tuschl, Clive R. Evjen Bramham
European Journal of Neuroscience 31 p. 636-645
2009

Remission of invasive, cancer stem-like glioblastoma xenografts using lentiviral vector-mediated suicide gene therapy

Peter Csaba Huszthy, Tsanan Giroglou, Oleg Tsinkalovsky, Philipp Euskirchen, Kai Ove Skaftnesmo, Rolf Bjerkvig, Dorothee von Laer, Hrvoje Miletic
PLoS ONE
2009

Highly infiltrative brain tumours show reduced chemosensitivity associated with a stem cell-like phenotype

Tor-Christian Aase Johannessen, Jian Wang, Kai Ove Skaftnesmo, Per Øystein Sakariassen, Per Øyvind Enger, Kjell Petersen, Anne Margrete Øyan, Karl-Henning Kalland, Rolf Bjerkvig, Berit Bølge Tysnes
Neuropathology and Applied Neurobiology 35 p. 380-393
2007

MicroRNAs in tumorigenesis

Kai Ove Skaftnesmo, Lars Prestegarden, David Robert Micklem, James Lorens
Current Pharmaceutical Biotechnology 8 p. 320-325
2006

Antitumor efficacy improved by local delivery of species-specific endostatin

Peter Csaba Huszthy, Christian Brekken, Tina Bugge Pedersen, Frits Alan Thorsen, Per Øystein Sakariassen, Kai Ove Skaftnesmo, Olav Haraldseth, Per Eystein Lønning, PE Lonning, Rolf Bjerkvig, Per Øyvind Enger
Journal of Neurosurgery 104 p. 118-128
2006

Primary glioma spheroids maintain tumourogenicity and essential phenotypic traits after cryopreservation

Eirik Sundlisæter, Jian Wang, Per Øystein Sakariassen, Michael Bruno Eric Marie, Juan Robbie Mathisen, Bård-Ove Karlsen, Lars Prestegarden, Kai Ove Skaftnesmo, Rolf Bjerkvig, Per Øyvind Enger
Neuropathology and Applied Neurobiology 32 p. 419-427
2006

Angiogenesis-independent tumor growth mediated by stem-like cancer cells

Per Øystein Sakariassen, Lars Prestegarden, Jian Wang, Kai Ove Skaftnesmo, Rupavathana Mahesparan, Carla Molthoff, Peter Sminia, Eirik Sundlisæter, Anjan Misra, Berit Bølge Tysnes, Martha Chekenya, Hans Peters, Gabriel Lende, Karl-Henning Kalland, Anne Margrete Øyan, Kjell Petersen, Inge Jonassen, Albert van der Kogel, Burt G. Feuerstein, A. Jorge A. Terzis, Rolf Bjerkvig, Per Øyvind Enger
Proceedings of the National Academy of Sciences of the United States of America 103 p. 16466-16471
2005

Distribution patterns of the anti-angiogenic protein ADAMTS-1 during rat development

Willy Günther, Kai Ove Skaftnesmo, Hans Arnold, Rolf Bjerkvig, A. Jorge A. Terzis
Acta Histochemica 107 p. 121-131

Annet tidsskriftbidrag

2013

EGFR wild-type amplification and activation promote invasion and development of glioblastoma independent of angiogenesis

Krishna Mukharji Talasila, Anke Soentgerath, Philipp Euskirchen, Gunnar Alm Rosland, Jian Wang, Peter Huszthy, Lars Prestegarden, Kai Ove Skaftnesmo, Per Øystein Sakariassen, Eskil Eskilsson, Daniel Stieber, Olivier Keunen, Janice Nigro, Olav Karsten Vintermyr, Morten Lund-Johansen, Simone P Niclou, Stian Mork, Per Øyvind Enger, Rolf Bjerkvig, Hrvoje Miletic
Neuro-Oncology 15 p. 6-6
2013

EARLY TUMOR DETECTION AND CHARACTERIZATION OF CHANGES IN TUMOR PERMEABILITY OF BRAINMETASTASES USING MULTIMODAL IMAGING

Frits Alan Thorsen, B Fite, Lisa M. Mahakian, Jai W. Seo, Shengping Qin, Victoria Harrison, Terje Sundstrøm, P Harter, Sarah Johnson, Elizabeth Ingham, Charles Caskey, Thomas J. Meade, Kai Ove Skaftnesmo, Katherine W. Ferrara
Neuro-Oncology 15 p. 241-241
2013

BRAIN-SPECIFIC GENE SIGNATURE OF MELANOMA METASTASIS

Terje Sundstrøm, Jobin K. Varughese, Patrick Harter, Lars Prestegarden, Kjell Petersen, Fransisco Azuaje, Clifford Tepper, Elizabeth Ingham, Lisa Even, Sarah Johnson, Kai Ove Skaftnesmo, Morten Lund-Johansen, Rolf Bjerkvig, Katherine W. Ferrara, Frits Alan Thorsen
Neuro-Oncology 15 p. 27-27
2009

Lentiviral Vectors Mediate Efficient Suicide Gene Therapy in an Invasive Xenograft Model of Human Glioblastoma

Hrvoje Miletic, Peter Csaba Huszthy, Tsanan Giroglou, Oleg Tsinkalovsky, P Euskirchen, Kai Ove Skaftnesmo, Rolf Bjerkvig, Dorothee von Laer
Molecular Therapy 17 p. S302-S302
2009

CD133-NEGATIVE GLIOMA SUBPOPULATIONS GROUPED BY DIFFERENT CELL TYPE MARKERS DISPLAY TUMORIGENICITY IN VIVO

Lars Prestegarden, Agnete Svendsen, Jian Wang, L Askland, A Persson, Per Øystein Sakariassen, Kai Ove Skaftnesmo, Randi Hovland, Per Øyvind Enger
Neuro-Oncology 11 p. 917-917
2004

Angiogenesis-independent growth by brain tumor cells exhibiting cancer stem cell properties

Per Øyvind Enger, Per Øystein Sakariassen, Kai Ove Skaftnesmo, Jian Wang, Eirik Sundlisæter, Lars Prestegarden, Anjan Misra, Berit Bølge Tysnes, Martha Chekenya, Burt G. Feuerstein, A. Jorge A. Terzis, Rolf Bjerkvig
Neuro-Oncology 6 p. 309-309

Rapporter og avhandlinger

2014

The Effect of miR-155 on the Expression of Annexin A2

Shalina Alom, Anni Vedeler, Kai Ove Skaftnesmo
2014

Visualization of metastatic melanoma cells by fluorescence microscopy and MRI using a novel glycogen nanoprobe

Synnøve Nymark Aasen, Frits Alan Thorsen, Kai Ove Skaftnesmo
2013

Glioblastoma multiforme; Tumor subclassification and the role of miR-7

Seyed Esmaeil Dorraji, Kai Ove Skaftnesmo, Rolf Bjerkvig
2013

Early life stress influences on stress handling in adulthood - development of depressive- and anxiety-like behavior in Wistar rats

Lasse Vesta, Clive R. Bramham, Kai Ove Skaftnesmo
2010

Model systems of human glioblastoma and characterization of microRNAs as therapeutic targets

Skaftnesmo, Kai Ove

Faglige foredrag

2018

Optimization of CRISPR/Cas9 knock-in technology and application in salmon

Rolf Edvardsen, Anne Hege Straume, Kai Ove Skaftnesmo, Lene Kleppe, hilal guralp, Anna Wargelius
2016

Targeting germ cell survival factors to produce sterile salmon

Lene Kleppe, Anna Wargelius, Helge Tveiten, Sven Dirk Leininger, Kai Ove Skaftnesmo, Tomasz Furmanek, Rüdiger W. Schulz, Geir Lasse Taranger, Eva Andersson, Rolf Edvardsen
2016

Targeting germ cell survival factors to produce sterile salmon through vaccination

Lene Kleppe, Anna Wargelius, Helge Tveiten, Sven Dirk Leininger, Kai Ove Skaftnesmo, Tomasz Furmanek, Rüdiger W. Schulz, Geir Lasse Taranger, Eva Andersson, Rolf Edvardsen
2016

Sterile salmon by targeting factors involved in germ cell survival: novel strategies for sustainable fish farming

Lene Kleppe, Rolf Edvardsen, Helge Tveiten, Sven Dirk Leininger, Kai Ove Skaftnesmo, Eva Andersson, Geir Lasse Taranger, Rüdiger W. Schulz, Tomasz Furmanek, Anna Wargelius
2016

Targeted mutagenesis in Atlantic salmon using the CRISPR/Cas9 system

Rolf Edvardsen, Lene Kleppe, Kai Ove Skaftnesmo, Sven Dirk Leininger, Tomasz Furmanek, Geir Lasse Taranger, Rüdiger W. Schulz, Eva Andersson, Anna Wargelius
2016

Bruk av CRISPR/Cas9 i laks

Rolf Edvardsen, Lene Kleppe, Kai Ove Skaftnesmo, Sven Dirk Leininger, Tomasz Furmanek, Geir Lasse Taranger, Rüdiger W. Schulz, Eva Andersson, Anna Wargelius
2016

Adaptive plasticity in Atlantic salmon- genetic predisposition of time at maturity and environmental triggers

Rolf Edvardsen, Erik Nordtorp Kjærner-Semb, Fernando Ayllon, Tomasz Furmanek, Tom Johnny Hansen, Per Gunnar Fjelldal, Carl Johan Rubin, Lene Kleppe, Kai Ove Skaftnesmo, Elin Sørhus, Faezeh Mohammadi, Geir Dahle, Vidar Wennevik, Monica Favnebøe Solberg, Kevin Glover, Birgitta Norberg, Geir Lasse Taranger, Eva Andersson, Rüdiger W. Schulz, Anna Wargelius
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