Reproduction and Developmental Biology
Gene expression pattern and level reflects to a significant extent the ongoing anatomical, morphological and physiological activities in a tissue and/or organism. My field of interest is functional genomics in Atlantic salmon with focus on the reproductive mechanisms. We currently use CRISPR-Cas9 to knockout (KO) genes in Atlantic salmon (Edvardsen et al 2014), to be able to 1) explore molecular mechanisms related to the reproductive system, in particular germ cell specification and early sexual development, and we have recently produce germ cell free salmon by ablation of the primordial germ cells using CRISPR-Cas9 knockout of the dnd gene (PGCs, (Wargelius et al 2016). Both aims explore fields which can result in sterility models for aquaculture that could solve major bottlenecks related to un-wanted sexual maturation and genetic interactions with wild populations. Currently two of my projects are intensively exploring these fields, SALMOSTERILE 2013-2018 (NFR BIOTEK 2021 project, https://www.hi.no/salmosterile/nb-no ) and POSTSMOLTMAR (HAVBRUK 2 2016-2020).
We have also in recent years explored the wild genome pool of Atlantic salmon with the main aim to identify genetic regions under selection for primarily reproductive traits, such as time at maturity (Ayllon et al 2015) However studies have also revealed genetic regions /sweeps that probably confer traits associated with disease resistance, behaviour, sea water adaption and feed metabolism (Kjærner-Semb et al 2016). SALMAT 2013-2017 (NFR-BIOTEK 2021-HAVBRUK project), MATGEN 2016-2020 (NFR _HAVBRUK) and DIGISAL (Biotek2021-digital life project).
Erik Kjærner-Semb. GWAS to find trais under selection
Shou Wang Current cosupervisor for PhD candidate in NFR FRIBIO project ” Deciphering embryonic segmentation, Genes that control the repeat pattern of the vertebral column.” 2011-2014 Thesis delivered Dec 18th 20
Lene Kleppe Current supervisor for PhD candidate in the EU project “LIFECYCLE”, (http://www.lifecycle-fp7.eu/). 2010-2013
Christel Krossøy Cosupervisor for PhD thesis, “Vitamin K in farmed Atlantic salmon (Salmo Salar L.) with emphasis on bone.”, dissertation for the degree philosophiae doctor (PhD), University of Bergen, Norway
Anna Sofie Troedsson-Wargelius (MSc, PhD)
Group leader, Principal Scientist (1183), Institute of Marine Research
DOB , 05.12.1972
Civil status Married, three children (6, 10 and 13 years)
FORMAL EDUCATION :
1998-2001 PhD Institute of Molecular Biology, University of Bergen, Norway
1991-1996 Master in Biology, University of Uppsala, Sweden